Autonomic Neural Blockade in Bariatric Surgery

Recruiting now · Not applicable

Conditions studied: Bariatric Surgery Candidate, Pain, Postoperative, Nausea and Vomiting, Postoperative, Opioid Use

In brief

The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.

Key facts

Study ID

NCT07104825

Run by

Endeavor Health

People needed

200

Starts

2026-02-05

Expected to finish

2027-12-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals able and willing to consent and participate in all study activities
• Adults, ages 18-90
• All patients with severe obesity undergoing laparoscopic/robotic gastric bypass or sleeve gastrectomy

You may not qualify if…

• Patients taking opiates chronically
• Patients allergic to study medications
• Patients with any prior adverse reaction to ingredients included in the block
• Adults unable to consent
• Pregnant women
• Prisoners

Where it is running

• Endeavor Health — Evanston, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.