Strength Training Response of Muscle in GLP-1 Users

Recruiting now · Not applicable

Conditions studied: Muscle Mass

In brief

GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.

Key facts

Study ID

NCT07104539

Run by

Virginia Polytechnic Institute and State University

People needed

30

Starts

2025-10-08

Expected to finish

2027-05-01

Last updated by the study team

2026-01-21

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age, 50y+
• Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less
• Weight <300 lb
• Pass a health and exercise readiness screening

You may not qualify if…

• Age <50
• Weight >300 lb
• Osteoporosis
• Active metabolic, neoplastic, or cardiovascular disease
• Unable or unwilling to provide consent

Where it is running

• Virginia Tech — Blacksburg, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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