Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws

Recruiting now · Not applicable

Conditions studied: Edentulous Alveolar Ridge, Edentulous Alveolar Ridge Atrophy

In brief

After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant placement to achieve successful dental rehabilitation and maximize implant survival and success rates. One possible method for reconstructing severe bone resorption is block bone augmentation. Due to its biological properties, autologous bone is considered the "gold standard" among bone graft materials, as it possesses osteoinductive, osteoconductive, and osteogenic properties. The advantages of using allografts over autologous bone grafts include reduced postoperative morbidity, decreased surgical time, and the absence of anatomical limitations regarding the amount of bone that can be harvested. The disadvantage of allografts is the loss of viable osteogenic cells and osteoinductive factors during processing. The aim of the study is: * to compare the success of the bone augmentation surgery depending on whether freeze-dried bone allograft blocks or autologous bone blocks are used, * compare the microarchitecture of the augmented bone depending on the bone graft material applied, * to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.

Key facts

Study ID

NCT07104370

Run by

Semmelweis University

People needed

30

Starts

2025-09-29

Expected to finish

2033-09-01

Last updated by the study team

2025-10-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• over 18 years old
• require lateral augmentation for implant rehabilitation

You may not qualify if…

• Smoking
• Pregnancy
• Poor oral hygiene
• Failure to attend follow-up visits
• Therapeutic-dose irradiation to the head and neck region
• Local bone tumors, cysts, or inflammatory processes
• Decompensated systemic diseases contraindicate surgery
• Use of medications affecting bone metabolism (steroids, antiresorptive medications such as bisphosphonates, RANKL inhibitor antibodies, VEGF antagonists)
• Psychiatric disorders contraindicate implant rehabilitation

Where it is running

• Semmelweis University Department of Public Dental Health — Budapest, Hungary, Hungary (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.