Influence of Antiseptic Washes on Wound Healing Complications After THA

Recruiting now · Not applicable

Conditions studied: Hip Osteoarthritis, Avascular Necrosis of Femur Head

In brief

The purpose of this research trial is to evaluate the effect of two types of washing solutions on wound healing after total hip replacement surgery. Washing solutions are used routinely during total hip replacements to clean the wound after the components have been placed and the wound is about to be closed with sutures. It is currently not known which washing solution may be better for wound healing and whether a certain solution decreases the risk of wound healing complications after total hip replacement. Therefore, this research trial is being conducted. Study participants will be randomized into one of two groups: washing the surgical wound with povidone-iodine solution (Surgiphor, Becton Dickinson, Franklin Lakes, NJ) or chlorhexidine solution (Irrisept, Irrimax Corporation, Lawrenceville, GA). All patients will undergo standard of care total hip replacements without any other change in surgery. The best type of solution that cleans the wound and potentially leads to better wound healing is unknown. This study will evaluate whether there is difference in surgical wound healing between the two washing solutions. The study will pay for the washing solutions. Patients will follow up for standard postoperative visits. At the 2-week and 6-week visits, pictures of the surgical incision will be taken and saved in the electronic medical record and evaluated in a standardized way for healing of the incision and the appearance of the scar. Postoperative complications and returns to the hospital or additional surgeries will be collected from the electronic medical record.

Key facts

Study ID

NCT07104084

Run by

F. Johannes Plate

People needed

420

Starts

2025-10-09

Expected to finish

2028-01-01

Last updated by the study team

2026-02-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• osteoarthritis or avascular necrosis of the femoral head, failed conservative management, indicated for total hip replacement

You may not qualify if…

• reported or documented allergy to chlorhexidine or povidone-iodine

Where it is running

• UPMC East — Monroeville, Pennsylvania, United States (enrolling)
• UPMC Shadyside — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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