A Study on the Effect of MRD Detected by FAPI PET / CT on the Recurrence of IgG4-RD
Recruiting now · Not applicable
Conditions studied: IgG4-Related Diseases
In brief
This study intends to use the new technology of fibroblast activation protein PET / CT to study whether the tiny residual lesions detected by 68Ga-FAPI PET / CT are related to the recurrence of IgG4-RD in patients with IgG4-RD who have been clinically evaluated for complete remission after treatment.
Key facts
- Study ID
- NCT07104058
- Run by
- Luo Yaping
- People needed
- 46
- Starts
- 2025-05-10
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-08-05
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age 18-75 years old ;
- Meet the 2019 ACR / EURLAR IgG4-RD diagnostic criteria ;
- The disease was stable for more than 1 year, and the clinical evaluation of the disease was complete remission * ;
- Glucocorticoid dosage ≤ prednisone 7.5mg / d × 6 months or more, or combined with an immunosuppressive therapy ( mycophenolate mofetil ) Ester ≤ 1.0g / d, leflunomide ≤ 20mg / d, methotrexate ≤ 15mg / w, azathioprine ≤ 100mg / d, iguratimod ≤ 25mg Bid )
You may not qualify if…
- ( 1 ) Combined with other connective tissue disease patients ( 2 ) patients with tumor ; ( 3 ) women during pregnancy or planning pregnancy ; ( 4 ) active infection, including HIV, HCV, HBV, TB, etc. ; ( 5 ) Severe irreversible organ damage ; ( 6 ) In the active stage of the disease, the IgG4-RD reaction index score of the single affected organ was 2 points ; ( 7 ) stable condition less than 1 year ; ( 8 ) patients who relapsed within 1 year of previous hormone reduction and withdrawal ; ( 9 ) Combination of two or more immunosuppressive agents.
Where it is running
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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