Inhaled Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Post-Infectious Cough: A Single-Center Randomized Controlled Clinical Trial

Recruiting now · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Post-Infectious Cough

In brief

This study is an exploratory clinical trial. It is intended to investigate the efficacy of mesenchymal stem cell-derived exosome nebulization in the treatment of postinfectious cough through a randomized controlled clinical study, with a view to providing better treatment options for patients with postinfectious cough, improving their quality of life, and providing reference data for the subsequent multi-center clinical trials.

Key facts

Study ID

NCT07103980

Run by

Shanghai Changzheng Hospital

People needed

40

Starts

2024-07-16

Expected to finish

2025-12-30

Last updated by the study team

2025-08-05

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18-60 years.
• Diagnosis of post-infectious cough, which is defined as: after the symptoms of acute respiratory infection have disappeared, chest radiographs are normal, irritating dry cough or cough with small amounts of mucoid phlegm occurs, cough persists for 3 to 8 weeks, and other causes of cough are ruled out.
• Baseline cough visual analog scale>=60mm.

You may not qualify if…

• patients with any other disease that causes coughing (eg, Upper airway cough syndrome, eosinophilic bronchitis, gastroesophageal reflux cough, bronchial asthma, chronic obstructive pulmonary disease and bronchiectasis).
• Patients with serious lung diseases (eg, lung cancer, tuberculosis or pulmonary fibrosis).
• Patients with serious comorbidities, (eg, cardiovascular, cerebrovascular, liver, kidney or hematopoietic system diseases or other serious primary diseases)
• Current or ex-smokers quitting smoking for less than 6 months.
• Patients with a body temperature ≥37.3℃.
• Patients with white blood cell count or neutrophil count is higher than the upper limit of normal.
• Patients with abnormal chest X-rays.
• Patients Suspected or confirmed history of alcohol or drug abuse or mental illness.
• Patients with pregnancy, lactation or planning pregnancy.

Where it is running

• Shanghai changzheng hospital — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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