IOA Preventing Occlusal Changes With MAD Use

Recruiting now · Not applicable

Conditions studied: Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite, Occlusal Changes, Tooth Migration, Posterior Open Bite

In brief

This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite. Participants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes. The study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.

Key facts

Study ID

NCT07103941

Run by

Isabel Moreno Hay

People needed

30

Starts

2025-11-17

Expected to finish

2026-12-30

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• adult participants (≥18 years)
• diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy
• Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.

You may not qualify if…

• pervious orthognathic surgery
• anterior cross bite
• posterior cross bite
• existing open bite or implant supported restorations
• tooth mobility
• significant dental caries or periodontitis
• severe bruxism
• planned upcoming dental work including caps, crowns, implants, or braces
• inadequate mandibular protrusion
• severe micrognathia
• large tori
• significant claustrophobia
• significant nasal obstruction
• large oropharyngeal masses or large tonsils

Where it is running

• Orofacial Pain Center - University of Kentucky - Kentucky Clinic — Lexington, Kentucky, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.