Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic

Recruiting now

Conditions studied: ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries, MINOCA, Microvascular Dysfunction, Microvascular Angina, Vasospastic Angina, Acetylcholine

In brief

Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of microcirculation and vasospastic disorders in causing angina. The microvascular bed is composed of vessels smaller than 400 microns in diameter. Their network is significantly larger than that of the epicardial vessels and serves essential functions, including regulating myocardial blood flow and cellular metabolism. Angina pectoris, a most frequent symptom of CAD or myocardial ischemia, was assumed to be caused by significant stenosis of the epicardial coronary artery. However, it was found that in over 50% of cases, there was no obstructive CAD, which is described as angina with no obstructive coronary arteries (ANOCA) or ischemia with no obstructive coronary arteries (INOCA), according to the clinical setting.

Key facts

Study ID

NCT07103317

Run by

University Hospital, Motol

People needed

1000

Starts

2023-04-20

Expected to finish

2030-01-01

Last updated by the study team

2025-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults of both sexes older than 18 years
• Angina symptoms or angina equivalent
• Referred to cath lab for evaluation of CAD
• Invasive physiology testing performed (microcirculation testing +/- vasospasm testing)

You may not qualify if…

• Persons under the age of 18
• Pregnant of nursing
• No coronary physiology measurements were performed

Where it is running

• University Hospital Motol — Prague, Česká Republika, Czechia (enrolling)

Full record on ClinicalTrials.gov

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