Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Recruiting now · Phase 4

Conditions studied: Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain, NSAIDs, Acetaminophen (D000082)

In brief

Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.

Key facts

Study ID

NCT07102641

Run by

Thomas Jefferson University

People needed

825

Starts

2025-08-26

Expected to finish

2027-12-01

Last updated by the study team

2025-09-03

Who can join

Age: 16 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• >/= 34 weeks gestation
• Singleton pregnancy
• Delivery via cesarean section under regional anesthesia

You may not qualify if…

• Contraindication to acetaminophen or NSAIDs
• Current or history of opioid use or misuse
• Intrauterine fetal demise
• Major congenital anomaly
• Conversion to general anesthesia intra-op or planned general anesthesia
• Mid-line vertical skin incision
• Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration

Where it is running

• Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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