Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain

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Conditions studied: Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease, Rheumatic Diseases, Musculoskeletal Diseases, Neuromuscular Disease, Fibromyalgia, Circadian Rhythm, Body Temperature Changes, Somatosensory Function, Quantitative Sensory Testing, Healthy

In brief

This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the movement evoked pain in healthy and patients with chronic primary pain (e.g., fibromyalgia). The intervention lasts 3 weeks with two treatment sessions per week.

Key facts

Study ID: NCT07101978
Run by: Bern University of Applied Sciences
People needed: 60
Starts: 2026-08-01
Expected to finish: 2028-12-31
Last updated by the study team: 2026-06-02

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

patients:
Confirmed diagnosis of widespread pain (ICD-11 MG30.01)
Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) scale ≥ 5 or WPI) ≥ 3 and SS ≥ 9,
Pain >= 3 month and VAS >= 4,0
Body - infrared-A-Bulb Distance < 38cm (overweight participants)
Signed declaration of consent
healthy:
No chronic illnesses
No acute infections
No regular medication: To avoid interactions
BMI ≤ 40kg/cm2
Mental health: No psychiatric diagnoses or psychotropic medication in your medical history

You may not qualify if…

Participation in other clinical studies
Contraindications for hyperthermia (severe cardiovascular diseases, tumour diseases, acute infections, pregnant and breastfeeding women)
Acute and / or feverish microbial infections
Participants with severe somatic, rheumatic concomitant endocrine or neurological diseases, in particular neurological diseases associated with cognitive disorders, severe liver or kidney and cardiac diseases
participants who are permanently treated with opioids, cannabis, immunosuppressive drugs (e.g. corticoids, immunosuppressants) or alpha/beta-A(nta)gonists due to a disease from the group described above
participants with pain due to a serious psychiatric illness (bipolar disorder, psychosis, personality disorder, severe depression, substance abuse) and serious systemic or neurological disorders
pregnancy or breastfeeding (for women)
Intake of medication within 6 weeks that inhibits the reuptake of the neurotransmitter serotonin or binds to receptors of this neurotransmitter group

Where it is running

Bern University of Applied Science — Bern, Canton of Bern, Switzerland

Full record on ClinicalTrials.gov

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