Preoperative Acetazolamide

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Post Operative Pain, Laparoscopic Hysterectomy, Referred Pain

In brief

The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.

Key facts

Study ID: NCT07101250
Run by: Prisma Health-Upstate
People needed: 100
Starts: 2025-10-30
Expected to finish: 2026-11-01
Last updated by the study team: 2026-02-20

Who can join

Age: 21 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Women
Ages 21-65
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy

You may not qualify if…

Allergy to acetazolamide or sulfonamides
Known electrolyte disturbances
Pregnancy
Kidney failure or creatinine >1.5
Diuretic or lithium use
Chronic obstructive pulmonary disease (COPD) or other lung disease
Central nervous system disorders
Liver disease
Glaucoma
Preoperative or chronic opioid use
Diagnosis of fibromyalgia
Preoperative shoulder pain
Conversion to laparotomy
Intraoperative bladder or bowel injury
Inability to understand or utilize visual analog scale
Undergoing concurrent reconstructive procedures

Where it is running

Prisma Health — Greenville, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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