Bacteria in Dental Plaque and Atheroma Plaque

Recruiting now

Conditions studied: Gingival Inflammation, Dental Plaque, Atheroma Plaque, Oral Bacteria

In brief

Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.

Key facts

Study ID

NCT07100574

Run by

Istanbul Saglik Bilimleri University

People needed

60

Starts

2024-12-10

Expected to finish

2026-03-30

Last updated by the study team

2025-08-03

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with endarterectomy
• Not receiving chemotherapy
• Not having received this treatment before

You may not qualify if…

• Having systemic infection
• Patients with severe heart disease

Where it is running

• Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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