PromotIng Optimal Treatment for Community-acquired PNeumonia in EmErgency Rooms
Recruiting now · Not applicable
Conditions studied: Community-Acquired Pneumonia (CAP), Pneumonia
In brief
In North America, up to 5% of preschoolers develop community-acquired pneumonia (CAP) every year. Pneumonia is the second-leading reason for paediatric hospitalization in both Canada and the US; approximately 20% of children hospitalized with CAP may need intensive care, which can result in significant morbidity. Given this burden of disease, it is critical that CAP is managed appropriately. Specific therapy for CAP is dependent on microbiologic aetiology, as bacterial disease will improve with antibiotic treatment.
Key facts
- Study ID
- NCT07099976
- Run by
- Jeffrey Pernica
- People needed
- 698
- Starts
- 2026-04-15
- Expected to finish
- 2030-05-15
- Last updated by the study team
- 2026-04-29
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Children aged 6 month to 18 years presenting to the Emergency Department who are diagnosed with CAP and are well enough to be discharged home (i.e. 'non-severe' CAP) will be eligible. They must have a fever (on exam or by history) and at least one of:
- Tachypnoea measured at triage (>60 bpm for age <1, >50 for 1-2 years of age, >40bpm for 2-4 years of age, and >30bpm for >4 years of age)
- Cough on exam or by history
- Increased work of breathing on exam
- Auscultatory finding (focal crackles, bronchial breathing, etc.) consistent with CAP
You may not qualify if…
- Children will be excluded if they have any of the following
- Cystic Fibrosis
- Anatomic Lung Disease
- Bronchiectasis
- Chronic Lung Disease requiring home oxygen or home ventilation
- Congenital heart Disease (requiring specific medical treatment or with exercise restrictions),
- History of repeated aspiration/velopharyngeal incompetence
- Malignancy
- Immunodeficiency (primary, acquired or iatrogenic)
- Pneumonia previously (clinically) diagnosed within the past month (that was presumed to have resolved prior to the episode prompting the current visit to the ED)
- Lung abscess within the past 6 months
- Children who present with ongoing fever after 4 days of amoxicillin, cefprozil, cefuroxime, levofloxacin, moxifloxacin or doxycycline are not eligible; as this duration of therapy with these drugs would normally be sufficient to treat bacterial CAP, a different approach would be required (ie. the care pathway as written might not be appropriate).
- Children will not be eligible to participate more than once
Where it is running
- Alberta Children's hospital — Calgary, Alberta, Canada (enrolling)
- Children's Hospital of Eastern Ontario (CHEO) — Ottawa, Ontario, Canada (enrolling)
- Stollery Children's Hospital — Edmonton, Alberta, Canada
- BC Children's Hospital — Vancouver, British Columbia, Canada
- McMaster Children's Hospital — Hamilton, Ontario, Canada
- The Hospital for Sick Children — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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