Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application

Recruiting now

Conditions studied: Thoracic, Surgery, Mechanical Ventilation, Hypercapnia, Acidosis, One Lung Ventillation (OLV), Smartphone Application

In brief

One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce postoperative respiratory complications. Protective ventilation during one-lung ventilation is specific since tidal volumes are applied by definition to one lung, and it is recommended to use lower tidal volumes, down to 4 ml/kg of ideal body weight. This approach requires individualized ventilation parameters, which differs from the conventional or two-lung ventilation, and there are no clear recommendations regarding respiratory rate adjustment to ensure adequate gas exchange.

Key facts

Study ID

NCT07099963

Run by

Laval University

People needed

100

Starts

2025-08-01

Expected to finish

2026-06-01

Last updated by the study team

2025-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults (≥ 18 years old)
• Patients intubated and undergoing one-lung ventilation during thoracic surgery
• Volume-controlled ventilation mode used intraoperatively

You may not qualify if…

• Arterial blood gas data unavailable during one-lung ventilation
• Missing demographic data (sex, height, actual weight)

Where it is running

• Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval — Québec, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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