The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

Recruiting now

Conditions studied: Septic Shock

In brief

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.

Key facts

Study ID

NCT07096284

Run by

Avicenna Military Hospital

People needed

30

Starts

2025-01-05

Expected to finish

2026-06-30

Last updated by the study team

2026-03-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia > 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). [Sepsis 3 criteria]

You may not qualify if…

• Absence of central venous access.
• Central venous access not positioned in the superior vena cava (e.g., femoral access).

Where it is running

• Avicenna Military Hospital — Marrakesh, Marrakesh, Morocco (enrolling)
• Avicenna Military Hospital — Marrakesh, Morocco (enrolling)
• Department of critical care Medicine. Avicenna Military Hospital — Marrakesh, Morocco (enrolling)

Full record on ClinicalTrials.gov

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