The LIFT-ECHO Last Mile Project

Starting soon · Not applicable

Conditions studied: Intestinal Failure

In brief

This is a multi-site research study to evaluate the efficacy and effectiveness of the LIFT-ECHO program to improve clinical outcomes in patients and improve patient reported quality of life (PRQOL). LIFT-ECHO (Learn Intestinal Failure Tele-ECHO) is a tele-health learning program whereby non-specialist clinicians meet with and learn from CIF specialist teams with the goal of improving the knowledge of CIF. LIFT-ECHO sessions consist of group discussion of anonymized real-world patient cases, followed by a didactic presentation from an expert in intestinal failure. Sessions are held twice a month and last 60-90 minutes. The study will proceed in three distinct phases, correlating with Project Aims. During phase 1 (Aim 1), an intestinal failure disease activity index (IF-DAI) will be developed as a measure of short- to medium-term clinical activity in CIF patients; this phase will be undertaken through Delphi Rounds. During Phase 2 (corresponding to project Aim 2), the researchers will evaluate the impact of physician participation in LIFT-ECHO on patients with CIF on PN. Lastly, Phase 3, corresponding to Aim 3 will be the dissemination of LIFT-ECHO nationally. For Phase 2, the researchers had originally proposed that patients and physicians will be recruited from the records of Optum Home Infusion services. Patient reported quality of life and clinical status will be assessed using surveys at baseline. Physicians will then be invited to participate in a module of LIFT-ECHO consisting of 8 one- hour-long sessions held over the course of 2-4 months. Patients will then be followed for 12 months to assess if physician participation in LIFT-ECHO improves patient reported quality of life and/or treatment efficacy and effectiveness. The main procedures for physician participants in the study include: completion of baseline and monthly surveys, possible participation in an appreciative inquiry workshop and possible participation in a focus group discussion, optional, but encouraged, participation in LIFT-ECHO. The main procedures for patient participants include: completion of surveys at baseline, participation in 12 monthly follow-up phone calls with a study team member. The proposed trial has a total length of 34 months.

Key facts

Study ID: NCT07094308
Run by: Icahn School of Medicine at Mount Sinai
People needed: 150
Starts: 2026-07-01
Expected to finish: 2030-06-30
Last updated by the study team: 2026-03-12

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

CIF patient participants must meet the following criteria in order to be considered eligible for participation:
Individuals of adult age (18 years or older), including pregnant women or Individuals of age > 5 years with parental consent and patient assent.
Diagnosis of chronic intestinal failure (ie. on PN >6 months with no malignancy, no HIV and a malabsorption or post-surgical diagnosis)
Currently receiving PN from a homecare infusion service company
Physician Inclusion Criteria:
Physician participants must meet the following criteria in order to be considered eligible for participation:
Individuals of adult age (18 years or older), including pregnant women
Hold an MD or DO degree
Be a licensed physician prescriber with a homecare infusion service company

You may not qualify if…

Participants meeting one or more of the following criteria will be excluded from participation:
Adults unable to consent (individuals with impaired decision-making capacity)
Prisoners
Children > 5 years who dissent

Where it is running

Icahn School of Medicine at Mount Sinai — New York, New York, United States
New York Academy of Medicine (NYAM) — New York, New York, United States
Rhode Island Hospital — Providence, Rhode Island, United States
University of Utah — Salt Lake City, Utah, United States
London School of Economics and Political Science — London, United Kingdom

Full record on ClinicalTrials.gov

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