Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
Recruiting now · Not applicable
Conditions studied: Substance Use, Healthy
In brief
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
Key facts
- Study ID
- NCT07094061
- Run by
- University of Michigan
- People needed
- 294
- Starts
- 2025-10-03
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-06-10
Who can join
Age: 18 and older, up to 22. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 18-22 years old at baseline
- Right-handed
- Medically/physically able to give informed consent
- English-speaking
- Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
You may not qualify if…
- Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
- History of psychosis in self or first-degree relative
- Current treatment for substance use disorder
- Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
- Intelligence quotient (IQ) < 70
- Lifetime history of head trauma with loss of consciousness > 5 minutes
- Reliance on glasses to be able to read small text at a distance of approximately 30 inches
- Colorblindness
- MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
Where it is running
- Rachel Upjohn Building — Ann Arbor, Michigan, United States (enrolling)
- University of Michigan — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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