Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study

Recruiting now · Not applicable

Conditions studied: Semen Analysis, ICSI, PGT-A

In brief

In assisted reproductive technology (ART), sperm preparation aims to select the most viable sperm for ICSI. Unlike conventional methods like density gradients or sperm washing, microfluidic techniques mimic natural selection in the female reproductive tract by using laminar flow without centrifugation, reducing the risk of DNA damage. This method isolates highly motile sperm while filtering out debris and immotile cells. Studies show that microfluidics improve embryo quality, increase pregnancy rates, and may lead to higher euploidy rates. Additional benefits include improved safety, scalability, and shorter preparation times.

Key facts

Study ID

NCT07093619

Run by

ART Fertility Clinics LLC

People needed

100

Starts

2025-09-12

Expected to finish

2026-12-30

Last updated by the study team

2025-10-02

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women with at least 8 MII per cycle after denudation (AFC≥8).
• Women of all ages.
• All embryo qualities ≥BL3CC at the time of biopsy on day 5, 6 and/or 7.
• Fresh sperm used from ejaculate with a concentration ≥1 mill/ml and ≥10% motility (A+B).
• Sperm samples with a minimum of 2 ml.

You may not qualify if…

• Frozen oocytes samples with severe oligospermia (≤1mill/ml).
• PGT-M cases
• Sperm with > 1M/ml of round cells

Where it is running

• ART Fertility Clinics LLC — Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates (enrolling)

Full record on ClinicalTrials.gov

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