Quality Improvement Intervention for a Safe Antimicrobial Use Reduction in Critically Ill Patients
Recruiting now · Not applicable
Conditions studied: Infection, Antimicrobial Stewardship, Critically Ill Intensive Care Unit Patients
In brief
The goal of this clinical trial is to learn if an educational intervention with audit and feedback on physicians and health care professionals who participate in antimicrobial treatment decisions can reduce the use of antimicrobials in adult patients admitted to a sample of Brazilian intensive care units (ICUs). The educational intervention is based on a literature review of current recommendations for a more rational use of antimicrobials and microbiological tests in daily ICU practice. The main questions it aims to answer are: * Does the educational intervention reduce the antimicrobial consumption in the intensive care units? * Does this educational intervention aiming to reduce antimicrobial utilization in accordance with the latest guidelines have any safety signals regarding ICU mortality rates or ICU length-of-stay? Researchers will compare (1) ICUs sequentially randomized to this quality improvement educational intervention aimed at improving antimicrobial utilization to (2) the same ICUs at months where the educational intervention has not been delivered yet. Each participant ICU will transition to the quality improvement intervention approximately each month, starting at July, 2025. This quality improvement intervention is based on current recommendations for antimicrobial stewardship from regulatory agencies and medical societies, including cognitive aids for physicians to improve decision-making regarding the commencement of antimicrobials, their duration and antimicrobial time-outs. The investigators hypothesize that intensivists (ICU doctors) need to embrace antimicrobial stewardship as a core competence of their daily activities.
Key facts
- Study ID
- NCT07093450
- Run by
- Hospital Sirio-Libanes
- People needed
- 9000
- Starts
- 2025-06-01
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2025-12-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Hospital Maternidade São José — Colatina, Espírito Santo, Brazil (enrolling)
- Santa Casa de Misericórdia de Passos — Passos, Minas Gerais, Brazil (enrolling)
- Hospital Municipal de Maringá — Maringá, Paraná, Brazil (enrolling)
- Hospital Pelópidas Silveira — Recife, Pernambuco, Brazil (enrolling)
- Hospital Naval Marcílio Dias — Rio de Janeiro, Rio de Janeiro, Brazil (enrolling)
- Hospital Onofre Lopes — Natal, Rio Grande do Norte, Brazil (enrolling)
- Hospital de Pronto Socorro — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)
- Hospital Santa Cruz — Santa Cruz do Sul, Rio Grande do Sul, Brazil (enrolling)
- Santa Casa de Misericórdia de Barretos — Barretos, São Paulo, Brazil (enrolling)
Full record on ClinicalTrials.gov
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