Understanding Freezing of Gait Using Brain Signals and Virtual Reality
Enrolling by invitation · Not applicable
Conditions studied: Parkinson&Amp;#39;s Disease, Freezing of Gait, Freezing of Gait Symptoms in Parkinson&Amp;#39;s Disease
In brief
Freezing of gait - the inability to start or continue walking - is a particularly disabling problem in Parkinson's disease that has few treatment options. This project records human brain activity from deep brain stimulation (DBS) devices during walking and freezing of gait episodes to understand the pathophysiology of freezing of gait. Findings will lay the foundation for the development of new treatment strategies that address this disabling symptom.
Key facts
- Study ID
- NCT07092995
- Run by
- University of California, Los Angeles
- People needed
- 36
- Starts
- 2025-11-01
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2026-02-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients meeting the MDS clinical diagnostic criteria for Parkinson's disease who are implanted with a Medtronic Percept DBS Device and SenSight Directional Leads in bilateral globus pallidus internus (GPi).
- Able to walk unassisted indoors
- Age 18 or older
- Half of patients will have disabling freezing of gait as defined by freezing more than once per day by self-report on questions 1 \& 2 of the New Freezing of Gait Questionnaire
- The other half of patients will not have freezing of gait as defined by self-report on question 1 of the New Freezing of Gait Questionnaire
You may not qualify if…
- Clinical diagnosis of dementia or severe cognitive impairment (MOCA < 21)
- History of stroke, traumatic brain injury, or other neurologic disorders besides Parkinson's disease
- Comorbidities causing severe gait impairments
- Unstable medical condition including cardio-vascular instability in the past 6 months
- Unable or unwilling to comply with the testing protocol
Where it is running
- University of California, Los Angeles — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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