Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries
Recruiting now · Not applicable
Conditions studied: Mechanical Ventilation, Lung Protective Ventilation, Driving Pressure
In brief
Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient. Lung protective ventilation provides breathing at a set volume determined by patient ideal body weight, along with a set rate to maintain adequate breathing. The pressures in the lower airway are kept less than 30 cm of H20 while a pressure of 5cm of H20 is applied to prevent lung collapse. Recently to above mentioned regimen a driving pressure is added which is a difference between lower airway pressure and pressure applied to prevent lung collapse. Ventilatory settings are adjusted to keep this driving pressure less than 15 cm of H2O.
Key facts
- Study ID
- NCT07092943
- Run by
- Rawalpindi Medical College
- People needed
- 70
- Starts
- 2025-07-20
- Expected to finish
- 2025-10-20
- Last updated by the study team
- 2025-07-30
Who can join
Age: 16 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- American Society of Anesthesiologists (ASA) class: I and II.
- Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation
- Patients receiving neuromuscular blockade during surgery.
- Receiving Mechanical ventilation for at least 1h.
You may not qualify if…
- Pregnancy
- Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks.
- Body mass index >35 kg/m2
- Smokers and ASA class III and above.
- Thoracic and Cardiac surgery
Where it is running
- Benazir Bhutto Hospital — Rawalpindi, Punjab Province, Pakistan (enrolling)
Full record on ClinicalTrials.gov
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