The Impact of Intraoperative Methadone on Postoperative Opioid Use

Withdrawn before enrolling · Phase 3

Conditions studied: Breast Cancer, Opioid Use

In brief

This is a single-institution, randomized controlled trial to assess the effectiveness of intraoperative methadone on postoperative opioid use, pain control, and recovery in patients undergoing autologous breast reconstruction. Findings from this trial would inform subsequent perioperative pain protocols and allow the possible integration of intraoperative methadone into multimodal analgesia protocols.

Key facts

Study ID

NCT07092475

Run by

University of Utah

People needed

0

Starts

2025-11-01

Expected to finish

2025-11-01

Last updated by the study team

2025-11-26

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients 18 years of age or older
• Patients undergoing unilateral or bilateral autologous breast reconstruction with abdominally-based free flaps after mastectomy for breast cancer or cancer prophylaxis

You may not qualify if…

• Patients undergoing reoperations such as autologous breast reconstruction as a revision procedure following failed implant-based reconstruction
• Patients undergoing multiple procedures such as mastectomy and immediate reconstruction
• Patients with documented chronic opioid use prior to procedure, or chronic pain condition

Where it is running

• Joy Ha — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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