Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Hypertension, Uncontrolled Hypertension

In brief

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension

Key facts

Study ID

NCT07090161

Run by

Vanda Pharmaceuticals

People needed

240

Starts

2025-09-15

Expected to finish

2026-11-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• SiSBP >/= 130 mmHg despite >8 weeks treatment w/ 1 or more antihypertensive therapies

You may not qualify if…

• Confirmed Grade 3/severe hypertension (SiSBP >/= 180 mmHg, SiDBP >/= 120 mmHg), unstable cardiac disease, renal insufficiency

Where it is running

• Vanda Investigative Site — Norfolk, Virginia, United States (enrolling)
• Vanda Investigative Site — Tempe, Arizona, United States (enrolling)
• Vanda Investigative Site — Tinley Park, Illinois, United States (enrolling)
• Vanda Investigative Site — El Dorado, Kansas, United States (enrolling)
• Vanda Investigative Site — Wichita, Kansas, United States (enrolling)
• Vanda Investigative Site — Lexington, Kentucky, United States (enrolling)
• Vanda Investigative Site — Hazelwood, Missouri, United States (enrolling)
• Vanda Investigative Site — Kinston, North Carolina, United States (enrolling)
• Vanda Investigative Site — Cincinnati, Ohio, United States (enrolling)
• Vanda Investigative Site — Norman, Oklahoma, United States (enrolling)
• Vanda Investigative Site — Charleston, South Carolina, United States (enrolling)
• Vanda Investigative Site — Burke, Virginia, United States (enrolling)
• Vanda Investigative Site — Chula Vista, California, United States (enrolling)
• Vanda Investigative Site — Dublin, California, United States (enrolling)
• Vanda Investigative Site — Walnut Creek, California, United States (enrolling)
• Vanda Investigative Site — Fort Myers, Florida, United States (enrolling)
• Vanda Investigative Site — Columbus, Georgia, United States (enrolling)
• Vanda Investigative Site — Oak Brook, Illinois, United States (enrolling)
• Vanda Investigative Site — Tucson, Arizona, United States
• Vanda Investigative Site — Phoenix, Arizona, United States
• Vanda Investigative Site — Carrollton, Texas, United States
• Vanda Investigative Site — Valencia, California, United States
• Vanda Investigative Site — Salt Lake City, Utah, United States
• Vanda Investigative Site — Doral, Florida, United States
• Vanda Investigative Site — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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