Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour Period

Completed · Phase 4 · Has a placebo group

Conditions studied: Vein Occlusion, Macular Degeneration Choroidal Neovascularization, Macular Edema, Diabetic Retinopathy

In brief

The goal of this clinical trial is to learn how various topical drops (bromfenac, loteprednol, and artificial tears) fare in alleviating post-intravitreal injection pain. The main questions it aims to answer are: \- Do bromfenac sodium and/or loteprednol etabonate improve post-injection pain scores compared to preservative-free artificial tears? Participants will: * Receive one drop of the topical drops five minutes prior to their regularly scheduled intravitreal injection. Depending on the treatment arm, they will also administer drops on their own at home up to 3 times per day on the day of their procedure. * They will answer a standardized pain score survey at 4 hours and 24 hours following their intravitreal injection and convey their results to study coordinators by phone.

Key facts

Study ID

NCT07090044

Run by

Retina Research Institute, LLC

People needed

77

Starts

2021-08-20

Expected to finish

2022-12-08

Last updated by the study team

2025-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Standard of Care Treatment with intravitreal injection
• History of at least 1 anti-VEGF injection in the 90 days prior to inclusion
• Less than 13 intravitreal injection in the 365 days prior to inclusion

You may not qualify if…

• History of autoimmune disease, graft versus host disease, neurotrophic corneal disease, contact lens use, keratitis, fibromyalgia, uveitis, herpetic ocular disease
• Drug allergy to any drug components
• History of any ocular surgery in the 30 days prior to inclusion
• Current topical corticosteroid or non-steroidal anti-inflammatory drug (NSAID)

Where it is running

• The Retina Institute — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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