The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

Recruiting now · Phase 4

Conditions studied: Knee Arthroplasty, Total, Knee Arthritis, Osteoarthritis, Total Knee Anthroplasty, Blood Loss, Tranexamic Acid Use, Epinephrine

In brief

The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty. Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration

Key facts

Study ID

NCT07089251

Run by

King Abdullah International Medical Research Center

People needed

80

Starts

2025-07-15

Expected to finish

2027-06-24

Last updated by the study team

2025-07-28

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing knee joint arthroplasty.
• Saudi and Non-Saudi Patient.
• Patients who have Complete medical record.

You may not qualify if…

• End stage renal disease
• Liver cirrhosis
• Coagulopathy
• Pre-operative Hgb <10 5.
• History of cerebrovascular accident or myocardial infarction in past 12 months.
• History of Heart failure.
• History of arrhythmia.
• History of pheochromocytoma, thyrotoxicosis and glaucoma.
• Pregnancy or breast feeding
• History of Deep venous thrombosis or pulmonary embolism
• Allergy to epinephrine or tranexamic acid

Where it is running

• King Abdulaziz Medical City, Ministry of National Guard - Health Affairs — Riyadh, Riyadh Region, Saudi Arabia (enrolling)

Full record on ClinicalTrials.gov

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