The Effect-site Concentration of Remifentanil Blunting Endotracheal Intubation Responses During Anesthesia Induction With Lidocaine or Sufentanil Combined With Etomidate: A Randomized Controlled Study
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Hemodynamics
In brief
The aim of this study was to compare the effect-site target concentration (including EC₅₀ and EC₉₀) of remifentanil required to suppress cardiovascular responses to tracheal intubation during anesthesia induction with etomidate combined with either lidocaine or sufentanil.
Key facts
- Study ID
- NCT07089173
- Run by
- Peking University Shenzhen Hospital
- People needed
- 99
- Starts
- 2025-08-01
- Expected to finish
- 2026-07-30
- Last updated by the study team
- 2025-09-22
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients scheduled for elective surgery under general anesthesia with endotracheal intubation;
- Classified as ASA physical status I-II.
You may not qualify if…
- Age <18 years or >65 years;
- Body mass index (BMI) >30 kg/m² or <18.5 kg/m²;
- Diagnosis of hypertension or severe cardiovascular diseases (including myocardial infarction, heart failure, atrial fibrillation, atrioventricular block, moderate-to-severe valvular diseases) or respiratory diseases (including acute exacerbation of chronic obstructive pulmonary disease, acute respiratory distress syndrome, acute asthma attack, moderate-to-severe pulmonary hypertension, severe pneumonia);
- Diagnosis of obstructive sleep apnea syndrome or history of difficult intubation or preoperatively anticipated difficult airway;
- Renal, hepatic or hematologic diseases;
- High risk of aspiration or reflux;
- Current use of analgesics for chronic pain or β-blockers for cardiovascular diseases;
- Current use of psychotropic medications;
- Contraindications to remifentanil or sufentanil, including: known hypersensitivity to any component of these drugs or other fentanyl analogues, current use of monoamine oxidase inhibitors, myasthenia gravis or conditions predisposing to respiratory depression, bronchial asthma or related disorders;
- Contraindications to lidocaine, including: known allergy to local anesthetics, concurrent Adams-Stokes syndrome, Wolff-Parkinson-White syndrome, or severe cardiac conduction block.
Where it is running
- Peking University Shenzhen Hospital — Shenzhen, Guangdong, China (enrolling)
Full record on ClinicalTrials.gov
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