Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Recruiting now

Conditions studied: Nephrectomy, Acute Kidney Injury, Biomarker

In brief

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

Key facts

Study ID

NCT07088874

Run by

Peking University First Hospital

People needed

60

Starts

2025-08-02

Expected to finish

2027-07-30

Last updated by the study team

2025-09-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years;
• Scheduled to undergo unilateral radical nephrectomy.

You may not qualify if…

• Solitary kidney;
• Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR <30 mL/min/1.73m²);
• Tumor invasion of the vena cava requiring thrombectomy;
• Other conditions deemed by the investigator as unsuitable for participation in this study.

Where it is running

• Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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