Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET

Recruiting now · Not applicable

Conditions studied: IVF, Frozen Embryo Transfer (FET), Embryo Thawing Protocol

In brief

The multi-step thawing protocol with a reduction of non-permeable cryoprotectant concentrations to reduce osmotic shock caused by the rapid influx of water. Recent studies have shown that a simplified warming protocol by only a thawing solution gave a comparable survival rate but increased pregnancy rate, reduced patients' waiting time, and decreased the workload of embryologists.

Key facts

Study ID

NCT07088640

Run by

Mỹ Đức Hospital

People needed

816

Starts

2025-08-13

Expected to finish

2027-03-01

Last updated by the study team

2025-09-12

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women aged from 18
• Undergoing no more than 3 previous IVF/ICSI cycles
• Had at least a single good-quality blastocyst frozen.
• Endometrium preparation using artificial cycle
• Agree to single blastocyst transfer
• Not participating in any interventional studies at the same time

You may not qualify if…

• Embryos from cycles after in-vitro maturation, pre-implantation genetic testing (PGT)
• Having contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease)
• Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx or endometrial polyp)

Where it is running

• My Duc Hospital — Ho Chi Minh City, City, Vietnam (enrolling)

Full record on ClinicalTrials.gov

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