Cannabichromene Safety in Rheumatoid Arthritis
Paused · Phase 1/Phase 2
Conditions studied: Arthritis, Rheumatoid
In brief
For this quantitative study, the investigators will collect data on human safety and side-effects of Cannabichromene (CBC) and whether CBC reduces blood inflammatory markers and Rheumatoid Arthritis (RA) disease activity. The participants will participate in an ABAB design with 2 doses of CBC across the A phases. They will attend 5 in-person clinic visits where they will have physical evaluations, complete self-report forms, and have blood drawn for the following tests: hs-CRP, ESR, IL-6, TNF, Complete Blood Count \[CBC\], and CMP.
Key facts
- Study ID
- NCT07087938
- Run by
- Crystal Lederhos Smith
- People needed
- 25
- Starts
- 2028-07-15
- Expected to finish
- 2030-05-31
- Last updated by the study team
- 2025-07-28
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Have a current diagnosis of RA
- Having stable treatment for at least 1 month prior to the study and being willing to continue that treatment for the duration of the study
- Having some degree of disease activity present at research study intake (determined by research study personnel)
- Aged 21+
- Able to read and speak English, and provide written consent
- Not currently pregnant or planning to become pregnant during the trial
- Not currently planning any surgeries during the course of the trial
- Willing to use a form of birth control for the duration of the study (all participants will be required to use birth control for the duration of the study)
- Willing to refrain from cannabis use (other than study provided CBC) over the course of the study
You may not qualify if…
- Do not have a current diagnosis of RA
- Has not received stable treatment for at least 1 month prior to the study or is unwilling to continue treatment for the duration of the study
- No degree of disease activity present at research study intake (determined by research study personnel)
- Under age 21
- Unable to read and speak English, or provide written consent
- Are currently pregnant or planning to become pregnant during the course of the trial
- Unwilling to use a form of birth control during the duration of the study
- Is planning a surgery during the course of their participation in the trial
- Unwilling to refrain from cannabis use (other than study provided CBC) over the course of the study
Where it is running
- Washington State University — Spokane, Washington, United States
Full record on ClinicalTrials.gov
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