Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases

Recruiting now · Not applicable

Conditions studied: Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System, MS (Multiple Sclerosis), NMOSD, Acute Disseminated Encephalomyelitis, Transcranial Alternating Current Stimulation

In brief

This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations. It also evaluates the effectiveness of transcranial electrical stimulation in alleviating clinical symptoms of IIDDs patients, and analyzes the key factors affecting the treatment efficacy. By uncovering the overall and individual characteristics of IIDDs, this study seeks to enhance therapeutic outcomes through personalized neuromodulation programs. The findings will provide a basis for applying non-invasive brain stimulation (NIBS) in IIDDs treatment and offer new ideas for future personalized medicine approaches.

Key facts

Study ID

NCT07087873

Run by

Xuanwu Hospital, Beijing

People needed

128

Starts

2025-05-30

Expected to finish

2027-10-31

Last updated by the study team

2025-07-28

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 18-60 years old.
• Diagnosis: Patients with neuromyelitis optica spectrum disease, multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system that meet the diagnostic criteria.
• Medications have been stable for at least three months.

You may not qualify if…

• Recurrence has been recorded in the past 3 months.
• Have a pacemaker or other metal implant in the body.
• Impaired skin integrity at the site of electrode placement.
• Previous organic brain disease such as epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infection.
• Combined with severe or unstable organic diseases, such as heart, liver and kidney and other organ dysfunction.
• Pregnant or lactating women, those who are planning to become pregnant in the near future.
• Patient compliance is poor.
• In the opinion of the investigator, there is a situation that is not suitable to participate in this study.

Where it is running

• Xuanwu Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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