Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Recruiting now · Not applicable

Conditions studied: Afib, Sleep Apnea Syndrome, Obstructive, CPAP

In brief

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

Key facts

Study ID

NCT07087587

Run by

The Cleveland Clinic

People needed

20

Starts

2025-08-25

Expected to finish

2026-12-31

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Informed consent
• Age 18-85 years
• High burden paroxysmal AF (≥1%)
• Moderate-severe OSA (AHI ≥ 15)
• Implanted device with atrial diagnostics
• Enrolled in remote monitoring

You may not qualify if…

• AF ablation <6 months
• Valvular abnormalities
• Excessive daytime sleepiness in safety-critical jobs
• Plans for ablation during study
• Non-CPAP OSA treatment
• Recent device implantation (<6 months)
• Central sleep apnea

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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