Cardiovascular Risk in Children With Chronic Conditions Study

Recruiting now

Conditions studied: Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease, Kawasaki Disease, Liver Transplant, Obesity and Overweight, Hypertension, Coarctation of Aorta, Bone Marrow Transplant, Cancer (Solid Tumors), Leukemia, Lymphoma, Lipoprotein(a), Aorta Stenosis, Non Alcoholic Fatty Liver Disease, Dyslipaemia, White Coat Hypertension, Pulmonary Hypertension, Juvenile Idiopahtic Arthritis, Systemic Lupus Erthematosus, Inflammatory Bowel Disease (IBD), HIV Infection, Transposition of Great Arteries

In brief

Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels. Although experts recognize this elevated risk and recommend close monitoring and early intervention, the underlying mechanisms driving this phenomenon remain poorly understood. At present, no effective interventions specifically target its root causes. Recent research shows that both large blood vessels (such as the carotid artery) and small vessels (such as those in the retina) can display early signs of damage decades before clinically apparent heart or vascular disease emerges. This accelerated vascular aging can result from multiple factors - including disease-related processes such as persistent inflammation and metabolic disturbances, treatment-related effects such as chemotherapy or long-term steroid use, and lifestyle changes associated with chronic illness, such as reduced physical activity and altered eating habits. However, it is still unclear how these factors influence the development and progression of vascular changes in children as they grow. Importantly, these changes can be monitored through non-invasive methods, offering a unique opportunity to study at-risk patients many years before overt cardiovascular disease develops. Identifying these early changes may enable us to detect and track individuals at heightened risk well in advance of clinical disease. This study aims to deepen our understanding of the causes of increased cardiovascular risk in children with chronic conditions and to lay the groundwork for earlier, more targeted prevention strategies.

Key facts

Study ID: NCT07086989
Run by: Semmelweis University
People needed: 300
Starts: 2025-04-01
Expected to finish: 2029-01-31
Last updated by the study team: 2025-08-08

Who can join

Age: 6 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Individuals aged between 6 and 25 years;
Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease;
Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study.
Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.

You may not qualify if…

Severe intellectual and developmental disability;
Decompensated heart failure;
Severe primary immunodeficiency;
Ongoing intravenous chemotherapy;
Infectious diseases posing a public health risk; or
History of regular alcohol or drug use.

Where it is running

Semmelweis University, Pediatric Center — Budapest, Hungary (enrolling)
Semmelweis University, Department of Surgery, Transplantation and Gastroenterology — Budapest, Hungary
Semmelweis University, Institute of Preventive Medicine and Public Health — Budapest, Hungary

Full record on ClinicalTrials.gov

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