Cocaine and Pentoxifylline (BED IN 47)
Recruiting now · Early Phase 1 · Has a placebo group
Conditions studied: Cocaine Use Disorder
In brief
This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.
Key facts
- Study ID
- NCT07086794
- Run by
- William Stoops
- People needed
- 30
- Starts
- 2025-11-10
- Expected to finish
- 2028-02-28
- Last updated by the study team
- 2026-06-08
Who can join
Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- able to speak/read English,
- not seeking treatment for drug use at the time of the study,
- female or male between the ages of 18 and 55 years,
- recent smoked or intravenous cocaine use verified by benzoylecgonine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for CUD,
- judged to be medically and psychiatrically healthy by study physicians other than the diagnosis for CUD at the time of screening,
- ECG, read by a cardiologist, within normal limits,
- females using an effective form of birth control and not pregnant or breastfeeding and 8) no known contraindications or allergies to pentoxifylline.
You may not qualify if…
- unable to speak/read English,
- seeking treatment for drug use,
- under 18 years or over 55 years,
- no recent smoked or intravenous cocaine use as indicated by benzoylecgonine negative urine and no DSM-5 diagnosis of CUD,
- judged to be medically or psychiatrically unhealthy by study physicians at the time of screening,
- ECG, read by a cardiologist, outside normal limits,
- females not using an effective form of birth control or pregnant or breastfeeding,
- contraindications or allergies to pentoxifylline, and
- Self-reported history of head trauma, seizure, CNS tumors, or use of concomitant medications that lower seizure threshold, or first-degree family history of seizures.
Where it is running
- Psychopharmacology of Addiction Laboratory — Lexington, Kentucky, United States (enrolling)
Full record on ClinicalTrials.gov
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