Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing

Recruiting now · Early Phase 1

Conditions studied: Palate; Wound

In brief

The goal of this clinical trial is to learn if the use of cyanoacrylate glue (PeriAcryl) is effective in healing of the palatal donor site in adults requiring a free gingival graft. The main question\[s\] it aims to answer \[is/are\]: Does PeriAcryl accelerate the palatal tissue healing compared with the use of collagen sponge? Does PeriAcryl usage leave the patients more satisfied? Researcher will compare the outcomes of participants treated with PeriAcryl to those treated with collagen sponge to see if PeriAcryl accelerated the healing process of palatal tissues and led to fewer postoperative complications. Participants will: * be assigned to a study group using PeriAcryl or control group using Collagen sponge. * be followed-up to monitor healing and gather clinical information.

Key facts

Study ID

NCT07086482

Run by

Beirut Arab University

People needed

22

Starts

2025-08-04

Expected to finish

2026-04-20

Last updated by the study team

2025-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Low-moderate anesthetic risk (ASA I-II)
• No restriction on ethnicity or gender
• Patients requiring FGG from the palate for periodontal plastic surgery
• Clinically healthy gingiva after phase I therapy
• Full-mouth plaque index grades 0 and 1
• Bleeding scores <15%

You may not qualify if…

• Patients who smoke > 10 cigarettes/day
• Patients with coagulation disorders
• Systemic diseases
• Patients on certain medications that may affect periodontal tissues
• Pregnant and lactating patient
• Patients with allergies to drugs that will be prescribed during the treatment phase
• Pathological mental conditions (dementia, psychosis) and lack of cooperation
• Excessive gag reflex

Where it is running

• Beirut Arab University — Beirut, Lebanon (enrolling)

Full record on ClinicalTrials.gov

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