Dexamethasone Versus Metoclopramide for Prophylaxis of Nausea and Vomiting After Cataract Surgery

Recruiting now · Not applicable

Conditions studied: Cataract, Dexamethasone

In brief

Postoperative nausea and vomiting (PONV) is a common consequence of ambulatory surgery, affecting up to 80% of high-risk patients and 20-30% overall. Despite being widespread, a prior survey found that patients are more averse to PONV than pain and other significant postoperative problems. Furthermore, even mild cases of PONV can have serious repercussions, such as postanesthesia care unit (PACU) workflow disruption, delayed discharges, higher medical costs, and lower patient satisfaction.PONV following intraocular surgery can be unpleasant and may lead to serious complications including suprachoroidal hemorrhage (SCH). SCH is a potentially serious condition that occurs when the posterior ciliary arteries or vortex veins burst, resulting in blood in the suprachoroidal region. The hypothesis is that dexamethasone will lower the incidence of PONV after cataract surgery when compared with metoclopramide.

Key facts

Study ID

NCT07086118

Run by

Alexandria University

People needed

210

Starts

2025-05-01

Expected to finish

2025-12-01

Last updated by the study team

2025-07-25

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 40-80 years, both sexes.
• ASA physical status class I to III.

You may not qualify if…

• history of motion sickness
• patients with gastrointestinal disorders or gastro-oesophageal reflux
• patients taking medications with known antiemetic activity
• previous postoperative vomiting
• allergy to bupivacaine
• allergy to metoclopramide or dexamethasone

Where it is running

• Alexandria University — Alexandria, Egypt (enrolling)

Full record on ClinicalTrials.gov

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