Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes

Recruiting now · Not applicable

Conditions studied: Sleep, Sleep Deprivation

In brief

This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.

Key facts

Study ID

NCT07085754

Run by

Yuhui Qiu

People needed

60

Starts

2025-08-08

Expected to finish

2026-12-31

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-40 years, gender not limited
• Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications
• Cognitively normal (Mini-Mental State Examination (MMSE) score > 28)
• Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)
• Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study

You may not qualify if…

• Presence of day-night sleep reversal
• Shift work within the past 6 months
• Travel across time zones or experience of jet lag within the past three weeks
• Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL [or 8 g] of pure alcohol)
• Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation
• Family history of early-onset dementia
• Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50
• Female participants who are currently pregnant or breastfeeding
• Individuals who need to drive or operate vehicles or machinery during the study period

Where it is running

• Guangdong Provincial Hospital of Chinese Medicine — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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