Neurofeedback and Cognitive Training for PBTS

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Brain Tumor, Primary

In brief

Brief Summary of the Study: This study is a prospective, randomized, sham-controlled, triple-blind trial investigating whether combining individualized alpha neurofeedback (NF) with cognitive training (Cogmed) can improve cognitive functioning in pediatric brain tumor survivors (PBTS), a group at risk for persistent cognitive difficulties after cancer treatment. Participants (ages 6-18) who have completed primary cancer therapy and report cognitive problems are randomly assigned to either (1) individualized alpha NF plus Cogmed or (2) sham NF plus Cogmed. Both interventions include eight one-hour sessions over four weeks, with neurofeedback (real or sham) followed by Cogmed training. The primary outcome is cognitive performance measured by CNS Vital Signs at baseline, post-intervention, and 12-month follow-up. Secondary outcomes include attention, executive function, behavior, and quality of life (measured by SWAN, BRIEF, SDQ, and PedsQL). The study uses rigorous double-blinding and intention-to-treat analysis, with sample size planned at 40-60 participants. Results will determine if individualized alpha NF, when combined with cognitive training, yields greater cognitive and behavioral benefits than cognitive training alone in PBTS.

Key facts

Study ID

NCT07085494

Run by

The University of Hong Kong

People needed

50

Starts

2025-08-01

Expected to finish

2028-08-31

Last updated by the study team

2026-01-27

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• - Paediatric brain tumour survivors aged 6 to 18 years
• Completion of primary cancer treatment (for example, surgery, chemotherapy, or radiotherapy) at least six months prior
• Documented or reported cognitive difficulties in attention or executive functioning
• Ability and willingness to attend scheduled sessions over four weeks

You may not qualify if…

• - Severe neurological or psychiatric conditions (for example, uncontrolled seizures) that preclude EEG monitoring or completing computer-based training
• Medication regimens that significantly interfere with EEG signals and cannot be safely adjusted
• Severe sensory or motor deficits that would make training infeasible
• Inability or unwillingness to follow study protocol

Where it is running

• Hong Kong Children's Hospital — Hong Kong, Hong Kong

Full record on ClinicalTrials.gov

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