A Study of LY3549492 in Healthy Weight Adult Participants

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Healthy

In brief

The main purpose of this study is to evaluate the safety and tolerability of LY3549492 in adult participants with a healthy body max index (BMI) of 22 to 25 kilograms per square meter (kg/m2). Participation in the study will last about 13 months.

Key facts

Study ID

NCT07085468

Run by

Eli Lilly and Company

People needed

1

Starts

2025-07-21

Expected to finish

2025-08-14

Last updated by the study team

2025-08-29

Who can join

Age: 55 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) within the range of 22 to 25 kilograms per square meter (kg/m2)
• Have had a stable body weight for 3 months prior to screening

You may not qualify if…

• Have type 1 diabetes, latent autoimmune diabetes in adults, or a history of ketoacidosis or hyperosmolar coma
• Have:
• type 2 diabetes and on antidiabetic therapy (except type 2 diabetes being managed with diet and/or stable dose of metformin)
• rare forms of diabetes mellitus, or
• hemoglobin A1c (HbA1c) >8%
• Have poorly controlled hypertension
• Have any of the following cardiovascular conditions within 12 months prior to screening:
• acute myocardial infarction
• stroke
• unstable angina, or
• hospitalization due to congestive heart failure.
• Have a history of New York Heart Association Functional Classification III or IV congestive heart failure
• Have signs and symptoms of liver disease
• Have a history of pancreatitis
• Have taken medications or alternative remedies for weight loss or weight gain within 3 months prior to screening

Where it is running

• Headlands Research - Scottsdale — Scottsdale, Arizona, United States
• Valley Clinical Trials, Inc. — Covina, California, United States
• Valley Clinical Trials, Inc. — Northridge, California, United States
• Peninsula Research Associates — Rolling Hills Estates, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• JEM Research Institute — Atlantis, Florida, United States
• Clinical Research Atlanta — Stockbridge, Georgia, United States
• Great Lakes Clinical Trials - Andersonville — Chicago, Illinois, United States
• Alliance for Multispecialty Research, LLC — Lexington, Kentucky, United States
• Alliance for Multispecialty Research, LLC — Norman, Oklahoma, United States
• Trial Management Associates — Myrtle Beach, South Carolina, United States
• Viacar Recherche Clinique — Greenfield Park, Canada
• Apex Trials — Guelph, Canada
• OCT Research ULC — Kelowna, Canada
• Clinique Mémoire de Montréal — Montreal, Canada
• Ottawa Memory Clinic — Ottawa, Canada
• Richmond Clinical Trials — Richmond, Canada
• Q&T Research Sherbrooke Inc. — Sherbrooke, Canada
• Toronto Memory Program — Toronto, Canada
• BioPharma Services — Toronto, Canada
• Diex Recherche Trois-Rivieres — Trois-Rivières, Canada

Full record on ClinicalTrials.gov

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