CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

Recruiting now

Conditions studied: Medulloblastoma

In brief

The study is being done to learn more about the long-term health and well-being of participants treated for medulloblastoma. The study is to decide which evaluations focusing on therapy-related lasting effects (or toxicities) should be considered. Medulloblastoma outcomes have improved with contemporary therapies including modern neurosurgical techniques and risk-adapted radiotherapy and chemotherapy regimens. However, survivors remain at risk for long-term health problems such as neurocognitive deficits, hearing loss, impaired cardiorespiratory fitness and physical performance, cardiac and neuroendocrine dysfunction, musculoskeletal conditions, and infertility.

Key facts

Study ID

NCT07085325

Run by

St. Jude Children's Research Hospital

People needed

184

Starts

2026-04-20

Expected to finish

2031-10-01

Last updated by the study team

2026-07-06

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of any subtype of medulloblastoma between the ages of 3 to 22 years or between the ages of 22 to 44 years with the sonic hedgehog (SHH) subtype of medulloblastoma
• Radiotherapy on or according to the SJMB12 protocol
• Received radiotherapy at St. Jude Children's Research Hospital
• 5 or more years since the initiation of radiation therapy and who did not have evidence of disease progression
• Provision of informed consent by participant/guardian or legal representative; Assent by minor participant
• Participants may choose to complete all or a subset of the proposed assessments; refusal to participate in some aspects of the study will not preclude participant inclusion
• Participants must also complete enrollment on SJLIFE

You may not qualify if…

• Participants or their legal guardian/representative are unwilling or unable to provide written informed consent.
• Participants who had relapsed or refractory disease during or following completion of treatment for medulloblastoma

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.