Dehydration, Rehydration, and Impact on Physiology
Recruiting now · Not applicable
Conditions studied: Aging
In brief
Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65. Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFkB), mitochondrial fragmentation, and autophagy in circulating PBMCs. Aim 2: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on fasting glucose, sleep performance, and strength performance. Participant will: complete a 4-day hydration protocol, followed by a 4-day dehydration protocol, and then a 4-day rehydration protocol. attend five laboratory visits for testing: Day 1: Informed consent and familiarization Day 2: Pre-hydration testing (before the 4-day hydration protocol) Day 3: Pre-dehydration testing (before the dehyration protocol) Day 4: Post-dehydration testing (after the dehydration protocol) Day 5: Post-rehydration testing (after the rehydration protocol)
Key facts
- Study ID
- NCT07084675
- Run by
- Texas Tech University
- People needed
- 15
- Starts
- 2025-07-15
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2025-09-17
Who can join
Age: 45 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Apparently Healthy
- BMI < 30 kg/m2
- Body weight is at least 110 lbs
You may not qualify if…
- Currently pregnant
- Have Type 1 Diabetes or Type 2 Diabetes
- Have chronic kidney disease or a history of kidney stones
- Have hypertension
- Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators
- Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)
Where it is running
- Texas Tech University — Lubbock, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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