Comparison of Outcomes of Management of Bowel Obstruction
Recruiting now · Phase 4
Conditions studied: Adhesive Small Bowel Obstruction
In brief
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
Key facts
- Study ID
- NCT07084441
- Run by
- University of Washington
- People needed
- 550
- Starts
- 2026-02-03
- Expected to finish
- 2030-12-01
- Last updated by the study team
- 2026-05-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults ≥18 years of age recruited from UWMC
- Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon.
- Diagnosis of aSBO is established by;
- CT findings consistent with diagnosis of SBO; and
- signs and symptoms consistent with SBO; and
- Adhesions from prior abdominopelvic surgery are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.).
- Ability to provide written or electronic informed consent in English and answer teach-back questions
You may not qualify if…
- Signs and symptoms of peritonitis with emergency operation planned
- Planned urgent operation within the next 12 hours
- Allergy to dexamethasone
- Surgery within prior 6 weeks
- Unable or unwilling to return or be contacted for and/or complete research surveys
- Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening
- Individuals with latent infections who have an increased risk of infection.
Where it is running
- Columbia University Medical Center — New York, New York, United States (enrolling)
- Harborview Medical Center — Seattle, Washington, United States (enrolling)
- UW Medical Center - Northwest — Seattle, Washington, United States (enrolling)
- University of Washington Medical Center Montlake — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
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