Evaluation of Tretinoin Cream on the Integrity of Aged Forearm Skin

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Skin Tear, Solar Purpura, Dermatoporosis

In brief

The purpose of this research is to determine whether once nightly application of tretinoin 0.1% cream to forearm skin reduces the frequency of skin tears and bruising (solar purpura), and changes skin thickness over a period of 6 months.

Key facts

Study ID

NCT07084116

Run by

James Thomas Pathoulas

People needed

15

Starts

2025-07-14

Expected to finish

2026-05-24

Last updated by the study team

2026-05-28

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (55+)
• History of skin tears, at least 2 in the past month
• History of skin bruising (solar purpura)
• Ambulatory
• Able to apply topical medication to oneself

You may not qualify if…

• <55 years old)
• Pregnant or breastfeeding
• History of allergy to tretinoin
• History of atopic dermatitis, psoriasis, bullous skin disease, cutaneous lupus, or cutaneous T cell lymphoma.
• Planned cutaneous surgery on either forearm in the next 6 months
• Use of any topical medication on the forearms within past month
• Current or anticipated phototherapy of the forearms in the next 6 months
• Current or anticipated chemotherapy within the next 6 months
• Use of oral steroids within past month
• Current or prior isotretinoin therapy within past 6 months
• AV fistula of the arm

Where it is running

• Palo Alto VA Medical Center — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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