Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders

Recruiting now

Conditions studied: Bleeding Disorders, Iron, Platelet, Bleeding

In brief

This is a prospective, single-arm, single-center observational study evaluating the impact of intravenous (IV) iron replacement in patients with inherited bleeding disorders and iron deficiency (ferritin \<50ng/dL). Subjects will undergo baseline bleeding assessments, quality-of-life measures, and laboratory tests before receiving standard-of-care IV iron. Follow-up blood work and questionnaires will be conducted post-replacement to assess for changes

Key facts

Study ID

NCT07083583

Run by

Nicoletta C Machin

People needed

40

Starts

2025-08-08

Expected to finish

2027-10-01

Last updated by the study team

2025-10-03

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and Females > 15 years of age
• Diagnosed with an Inherited Bleeding Disorder (Von Willebrand disease, platelet disorders, factor deficiencies, or bleeding disorder of unknown cause)
• Evidence of Iron Deficiency (Ferritin < 50 ng/mL)
• Receiving IV iron at Hemophilia Center of Western Pennsylvania
• Willingness to have blood drawn
• Willing to return to clinic 3 months post infusion for final blood draw, bleeding and quality of life assessments.

You may not qualify if…

• Previous thrombosis, VTE History.
• Platelet count < 100,000 * 109/L
• Concomitant use of antiplatelet drugs, anticoagulants, aspirin, NSAIDs.

Where it is running

• Hemophilia Center of Western Pennsylvania — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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