TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

Recruiting now · Phase 1

Conditions studied: Lymphoma, Lymphoma, Non Hodgkin

In brief

The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies in patients with relapsed or refractory Non-Hodgkin Lymphomas

Key facts

Study ID

NCT07082803

Run by

Treeline Biosciences, Inc.

People needed

180

Starts

2025-06-23

Expected to finish

2030-11-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Disease Characteristics
• Participant must have measurable disease at study entry
• Participants must have one of the following histologically documented hematologic malignancies:
• Diffuse large B-cell lymphoma (DLBCL), not otherwise specified (DLBCL, NOS), Follicular lymphoma (FL) grade 3b, or transformed lymphoma from FL following at least 2 prior lines of therapy.
• FL grade 1-3a that requires treatment following at least 2 prior lines of therapy.
• The following Peripheral T-cell lymphoma (PTCL) subtypes that have relapsed after, or not responded to at least 1 prior systemic treatment regimen:
• Nodal T-follicular helper (Tfh) cell lymphoma angioimmunoblastic; Follicular helper T-cell lymphoma, angioimmunoblastic type (AITL).
• Nodal Tfh cell lymphoma, follicular type; Follicular helper T-cell lymphoma, follicular type.
• Nodal Tfh cell lymphoma, NOS; Follicular helper T-cell lymphoma, NOS.
• High-Grade B-Cell Lymphoma that has relapsed after, or not responded to at least 2 prior systemic treatment regimens.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

You may not qualify if…

• Participants must not have current central nervous system (CNS) involvement. Participants with past history of CNS involvement of lymphoma must have had CNS disease fully treated with no evidence of recurrence within 12 months.
• Participant must not have a history of autologous stem cell transplantation within 60 days or allogeneic stem cell transplantation within 90 days prior to the start of the study.
• Participant must not have a history of CAR T-cell or other T-cell targeting treatment ≤ 4 weeks prior to the start of the study.
• Participant must not have major surgery or severe trauma within 4 weeks prior to the start of the study.
• Participants must not have any condition, including significant acute or chronic medical illness, active or uncontrolled infection, or the presence of laboratory abnormalities, that places participants at unacceptable risk if participating in this study.
• Pregnant or lactating.
• Conditions that could affect drug absorption.

Where it is running

• Stanford Medicine Cancer Center — Palo Alto, California, United States (enrolling)
• The START Center for Cancer Care - Midwest — Grand Rapids, Michigan, United States (enrolling)
• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• Weill Cornell Medicine - New York Presbyterian Hospital — New York, New York, United States (enrolling)
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• SCRI Oncology Partners — Nashville, Tennessee, United States (enrolling)
• The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Macquarie University Hospital — Macquarie Park, New South Wales, Australia (enrolling)
• Princess Alexandra Hospital — Woolloongabba, Queensland, Australia (enrolling)
• Cabrini Health — Malvern, Victoria, Australia (enrolling)
• Peter MacCallum Cancer Centre — Melbourne, Victoria, Australia (enrolling)
• Linear Clinical Research — Perth, Western Australia, Australia (enrolling)
• BC Cancer - Vancouver — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.