A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Recruiting now · Phase 1/Phase 2
Conditions studied: Relapsed AL Amyloidosis, Refractory AL Amyloidosis, Light Chain Amyloidosis, Amyloidosis
In brief
Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.
Key facts
- Study ID
- NCT07081646
- Run by
- Alexion Pharmaceuticals, Inc.
- People needed
- 91
- Starts
- 2025-08-18
- Expected to finish
- 2031-02-14
- Last updated by the study team
- 2026-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Confirmed histopathological diagnosis of AL amyloidosis
- One or more organs currently or historically impacted by AL amyloidosis according to consensus guidelines
- Measurable hematologic disease: dFLC > 20 mg/L or serum M-protein > 5g/L
- Relapsed or refractory disease with a need for additional therapy after at least 1 line of anti-plasma cell-directed therapy.
- ECOG performance status of 0 to 2
- Must be able and willing to adhere to the study visit schedule and other protocol requirements
- Women of child-bearing potential (WCBP) must have a negative serum and/or urine pregnancy test result prior to treatment. All sexually active WCBP and all sexually active male subjects must agree to use highly effective methods of birth control throughout the study.
You may not qualify if…
- Have any other form of amyloidosis other than AL amyloidosis
- Mayo Stage IIIb AL amyloidosis
- Oxygen saturation < 95% on room air
- Systolic blood pressure <100mmHg
- NYHA class III or IV
- Extensive GI involvement with evidence of active GI bleeding/risk of bleeding as determined by Investigator
- Prior therapies:
- CAR T cell therapy directed at any target
- Prior BCMA-targeting therapy
- Prior treatment with any FDA approved or investigational T cell engaging therapies (including T cell-directed bispecific or trispecific therapies) at any target within the last 6 months.
- Toxicity from previous anti-cancer or anti-PC-directed therapy did not resolve to baseline levels or to Grade 1 or less except for alopecia or peripheral neuropathy.
- Active plasma cell leukemia at the time of screening
- Symptomatic multiple myeloma (defined as clonal bone marrow plasma cells ≥10% plus at least one myeloma-defining event per IMWG 2014)
Where it is running
- Research Site — London, United Kingdom (enrolling)
- Research Site — San Francisco, California, United States (enrolling)
- Research Site — Tampa, Florida, United States (enrolling)
- Research Site — Boston, Massachusetts, United States (enrolling)
- Research Site — Detroit, Michigan, United States (enrolling)
- Research Site — Rochester, Minnesota, United States (enrolling)
- Research Site — St Louis, Missouri, United States (enrolling)
- Research Site — New York, New York, United States (enrolling)
- Research Site — New York, New York, United States (enrolling)
- Research Site — New York, New York, United States (enrolling)
- Research Site — Cleveland, Ohio, United States (enrolling)
- Research Site — Nashville, Tennessee, United States (enrolling)
- Research Site — Calgary, Alberta, Canada (enrolling)
- Research Site — Toronto, Ontario, Canada (enrolling)
- Research Site — Phoenix, Arizona, United States (enrolling)
- Research Site — Calgary, Alberta, Canada
- Research Site — London, United Kingdom
- Research Site — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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