Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions

Recruiting now

Conditions studied: Acute Myeloid Leukemia, NPM1 Mutation

In brief

This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.

Key facts

Study ID

NCT07080970

Run by

Gruppo Italiano Malattie EMatologiche dell'Adulto

People needed

220

Starts

2026-07-01

Expected to finish

2028-11-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with de novo AML, untreated, newly diagnosed, according to WHO/ICC 2022 criteria from January 2015 onwards.
• Presence of NPM1 mutation.
• Availability of immunophenotypic characterization at diagnosis
• Age >= 18 years
• Signed written informed consent according to ICH/EU/GCP and national local laws (if applicable)

You may not qualify if…

• No specific exclusion criteria are provided once eligibility criteria are met.

Where it is running

• SOD Ematologia, Università di Firenze, AOU Careggi — Florence, Italy (enrolling)

Full record on ClinicalTrials.gov

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