Manipulating the Peri-Infarct Area Using Maraviroc to Enhance Motor Skills After Stroke
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Ischemic Stroke, Stroke, Stroke Acute
In brief
MASTER is a single-center, patient and investigator-blinded, Randomized Controlled Trial (RCT) to compare the efficacy of Maraviroc, a C-C chemokine receptor 5 (CCR5) antagonist, against placebo regarding motor function and motor learning skills in the first 3 months after ischemic stroke.
Key facts
- Study ID
- NCT07080567
- Run by
- Emmanuel Carrera
- People needed
- 80
- Starts
- 2025-07-14
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2025-08-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed consent as documented by signature
- ≥18 years at time of signing of informed consent
- Acute ischemic stroke.
- Stroke onset < 7 days from randomization.
- Contralateral, unilateral, incomplete upper limb paresis, incl. :
- FMA-UE < 63/66
- Residual voluntary finger extension (VFE) of > 10 degrees
You may not qualify if…
- Pregnancy/lactation or positive pregnancy test in women of childbearing age
- Pre-stroke handicap (mRS > 2)
- Diseases affecting motor function (e.g., Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS))
- Participation in another study with investigational medicinal product within 30 days preceding and during the present study
- Enrolment of the investigator, his/her family members, employees, or other dependent persons
- Known hypersensitivity to Maraviroc, Mannitol, peanuts, or soy
- History of significant liver disease, hepatitis, elevated liver function tests (> 1.5 upper limit of normal)
- History of significant renal disease or End Stage Renal Disease/dialysis, acute renal injury, Creatinine Clearance (CrCl < 30ml/min/1.73m2)
- Patients with cardiovascular comorbidities and risk for orthostatic hypotension
- HIV infection
- Concomitant use of strong CYP3A4 inhibitors or inducers
Where it is running
- Geneva University Hospital — Geneva, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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