A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Recruiting now · Phase 1/Phase 2
Conditions studied: Metastatic Colorectal Cancer
In brief
This randomized, multi-site, three-part study will test a new treatment called BNT314, which is designed to help the body's own defense to fight cancer in combination with another new treatment (pumitamig, which is a cancer immunotherapy drug also known as BNT327 and PM8002) and chemotherapy in participants with metastatic colorectal cancer (mCRC).
Key facts
- Study ID
- NCT07079631
- Run by
- BioNTech SE
- People needed
- 482
- Starts
- 2025-07-18
- Expected to finish
- 2032-12-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yale University — New Haven, Connecticut, United States (enrolling)
- START Midwest — Grand Rapids, Michigan, United States (enrolling)
- Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center — Cleveland, Ohio, United States (enrolling)
- The University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Hämatologisch-Onkologische Praxis Eppendorf - HOPE — Hamburg, Germany (enrolling)
- Asklepios Tumorzentrum Hamburg — Hamburg, Germany (enrolling)
- National Cancer Center Hospital — Chūōku, Japan (enrolling)
- National Cancer Center Hospital East — Kashiwa, Japan (enrolling)
- Hospital HM Nou Delfos — Barcelona, Spain (enrolling)
- Vall D'Hebrón Hospital — Barcelona, Spain (enrolling)
- Centro Integral Oncologico Clara Campal — Madrid, Spain (enrolling)
- Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital — London, United Kingdom (enrolling)
- Christie NHS Foundation — Manchester, United Kingdom (enrolling)
- The Royal Marsden NHS — Sutton, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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