Long-term Follow-up of Depressive Disorders in Psychiatric Care
Recruiting now
Conditions studied: Depression, Psychiatric Diagnosis, Personality Disorders, Suicide, Attempted, CYP2D6 Polymorphism, Anhedonia
In brief
The project investigates long-term prognosis and predictors of treatment outcomes for difficult-to-treat depression in patients in secondary psychiatric care. The current patient cohort was collected in 2012-2021 in the study "Pharmacogenetics in patients with depression with specific focus on difficult-to-treat depression, suicide attempt and CYP2D6". The cohort consists of 415 patients, examined carefully regarding diagnostic assessment and earlier treatment. All participants were also genotyped for the drug metabolizing enzymes CYP2D6 and CYP2C19. Blood samples were stored in biobank for other analyses linked to prognostic markers. The patient cohort will now be followed up with a review of medical records and extraction of register data for a period of 5 years after their participation in the original study. The purpose of the study is to improve treatment and increase knowledge about long-term prognosis in difficult-to-treat depression. This is done by examining symptom profiles, monitoring clinical course and suicidality, and examining prognostic markers.
Key facts
- Study ID
- NCT07078227
- Run by
- Region Skane
- People needed
- 415
- Starts
- 2025-06-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participation in the study "Pharmacogenetics in depressive patients with specific focus on difficult-to-treat depression, suicide attempt and CYP2D6"
You may not qualify if…
- Not wanting to participate in the follow-up study
Where it is running
- Research Unit, Office of Psychiatricy, habilitation and technical aid — Lund, Sweden (enrolling)
- Psychiatry Reserach Unit — Lund, Sweden
Full record on ClinicalTrials.gov
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