Comparative Analysis of Intraoperative Effect Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Spinal Anaesthesia in Lower Limb Orthopedic Surgeries to Evaluate the Hemodynamic Stability and Onset and Duration of Motor Block of Using Intrathecal Dexmedetomidine and Fentanyl
Recruiting now · Phase 4
Conditions studied: Spinal Anesthesia Duration
In brief
Spinal anesthesia is the most widely employed procedure for lower limb orthopedic operations, as it is very cost-effective and simple to apply. These advantages could be restricted because presently existing local anesthetic drugs had relatively short length of action. (1) Spinal anesthesia with 0.5% heavy bupivacaine (hyperbaric) is a common technique, still there was burden of its short duration of action. To overcome this issue, there was a continuous search for an ideal adjuvant.(2) Adjuvants were mostly added to local anesthetic drugs to increase their effectiveness, speedy onset, increase the period of the block, and reduce the local anesthetics dosage, thus reduction their adverse effects.(3) Such adjuvants had been beneficial in extension of analgesia along with initiation of movement though their related side effects.(4)
Key facts
- Study ID
- NCT07078201
- Run by
- Nashwa Ahmed
- People needed
- 40
- Starts
- 2025-07-01
- Expected to finish
- 2025-12-25
- Last updated by the study team
- 2025-12-30
Who can join
Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The patient aged range from 20 to 60 years
- ASA 1 and 2
- Patient prepared for elective lower limb orthopaedic surgeries.
- Height 150-180 cm.
- Weight 50-70 kg. 6- Either sex male or female.
You may not qualify if…
- 1- Patient refusal. 2- Patient had absolute contraindication to spinal anaesthesia. 3-Patients with neurological disorders, pregnancy, local infection at the site of injection.
- 4- Patients suffering from dysrhythmia or heart block. 5- Patients with ASA 3 or more.
Where it is running
- Port said university — Port Said, Egypt (enrolling)
Full record on ClinicalTrials.gov
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